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3bgw

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[[Image:3bgw.png|left|200px]]
 
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{{STRUCTURE_3bgw| PDB=3bgw | SCENE= }}
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==The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase==
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<StructureSection load='3bgw' size='340' side='right'caption='[[3bgw]], [[Resolution|resolution]] 3.91&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bgw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpspp Bpspp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bho|3bho]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">G40P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10724 BPSPP])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgw OCA], [https://pdbe.org/3bgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgw RCSB], [https://www.ebi.ac.uk/pdbsum/3bgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgw ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicases are essential enzymes for DNA replication, a fundamental process in all living organisms. The DnaB family are hexameric replicative helicases that unwind duplex DNA and coordinate with RNA primase and other proteins at the replication fork in prokaryotes. Here, we report the full-length crystal structure of G40P, a DnaB family helicase. The hexamer complex reveals an unusual architectural feature and a new type of assembly mechanism. The hexamer has two tiers: a three-fold symmetric N-terminal tier and a six-fold symmetric C-terminal tier. Monomers with two different conformations, termed cis and trans, come together to provide a topological solution for the dual symmetry within a hexamer. Structure-guided mutational studies indicate an important role for the N-terminal tier in binding primase and regulating primase-mediated stimulation of helicase activity. This study provides insights into the structural and functional interplay between G40P helicase and DnaG primase.
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===The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase===
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The structure of a DnaB-family replicative helicase and its interactions with primase.,Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS Nat Struct Mol Biol. 2008 Jan;15(1):94-100. Epub 2007 Dec 23. PMID:18157148<ref>PMID:18157148</ref>
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{{ABSTRACT_PUBMED_18157148}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3bgw" style="background-color:#fffaf0;"></div>
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[[3bgw]] is a 6 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_spp1 Bacillus phage spp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGW OCA].
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==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018157148</ref><references group="xtra"/>
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__TOC__
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[[Category: Bacillus phage spp1]]
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</StructureSection>
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[[Category: Chen, X S.]]
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[[Category: Bpspp]]
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[[Category: Holden, L G.]]
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[[Category: Large Structures]]
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[[Category: Klein, M G.]]
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[[Category: Chen, X S]]
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[[Category: Tokonzaba, E.]]
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[[Category: Holden, L G]]
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[[Category: Wang, G.]]
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[[Category: Klein, M G]]
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[[Category: Zhang, Y.]]
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[[Category: Tokonzaba, E]]
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[[Category: Wang, G]]
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[[Category: Zhang, Y]]
[[Category: Atpase]]
[[Category: Atpase]]
[[Category: Replication]]
[[Category: Replication]]

Current revision

The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase

PDB ID 3bgw

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