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Plexin

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Line 33: Line 33:
**[[5l5l]] – mPLX-A4 extracellular domain segment 1-8<br />
**[[5l5l]] – mPLX-A4 extracellular domain segment 1-8<br />
**[[5l5m]], [[5l5n]] – mPLX-A4 extracellular domain segment 1-7<br />
**[[5l5m]], [[5l5n]] – mPLX-A4 extracellular domain segment 1-7<br />
 +
**[[7m0r]] – mPLX-A4 + neuropilin + semaphorin - CryoEM<br />
**[[6fkm]], [[6fkn]] - PLX-A + semaphoring – ''Drosophila melanogaster''<br />
**[[6fkm]], [[6fkn]] - PLX-A + semaphoring – ''Drosophila melanogaster''<br />
Line 50: Line 51:
**[[4e71]] - hPLX-B2 effector domain<br />
**[[4e71]] - hPLX-B2 effector domain<br />
**[[5e6p]] - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11<br />
**[[5e6p]] - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11<br />
 +
**[[7kdc]] – mPLX-B2 receptor binding domain 1463-1565 + RhoD<br />
*Plexin C
*Plexin C

Revision as of 08:55, 13 January 2022

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

3D structures of plexin

13-January-2022

References

  1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
  2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
  3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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