This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j3w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 19 January 2022) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2j3w.png|left|200px]]
 
-
<!--
+
==The crystal structure of the bet3-trs31-sedlin complex.==
-
The line below this paragraph, containing "STRUCTURE_2j3w", creates the "Structure Box" on the page.
+
<StructureSection load='2j3w' size='340' side='right'caption='[[2j3w]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2j3w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J3W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-
-->
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j3r|2j3r]], [[2j3t|2j3t]]</div></td></tr>
-
{{STRUCTURE_2j3w| PDB=2j3w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j3w OCA], [https://pdbe.org/2j3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j3w RCSB], [https://www.ebi.ac.uk/pdbsum/2j3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j3w ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j3w_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j3w ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to elucidate the architecture of TRAPP I. The complex is organized through lateral juxtaposition of the subunits into a flat and elongated particle. We have also localized the site of guanine nucleotide exchange activity to a highly conserved surface encompassing several subunits. We propose that TRAPP I attaches to Golgi membranes with its large flat surface containing many highly conserved residues and forms a platform for protein-protein interactions. This study provides the most comprehensive view of a multisubunit vesicle tethering complex to date, based on which a model for the function of this complex, involving Rab1-GTP and long, coiled-coil tethers, is presented.
-
===THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.===
+
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.,Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M Cell. 2006 Nov 17;127(4):817-30. PMID:17110339<ref>PMID:17110339</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17110339}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2j3w" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17110339 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17110339}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Brachidanio rerio]]
-
2J3W is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3W OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Lk3 transgenic mice]]
-
==Reference==
+
[[Category: Kim, Y G]]
-
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering., Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M, Cell. 2006 Nov 17;127(4):817-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17110339 17110339]
+
[[Category: Oh, B H]]
-
[[Category: Danio rerio]]
+
-
[[Category: Mus musculus]]
+
-
[[Category: Protein complex]]
+
-
[[Category: Kim, Y G.]]
+
-
[[Category: Oh, B H.]]
+
[[Category: Endoplasmic reticulum]]
[[Category: Endoplasmic reticulum]]
[[Category: Er-golgi transport]]
[[Category: Er-golgi transport]]
Line 39: Line 46:
[[Category: Trapp]]
[[Category: Trapp]]
[[Category: Vesicle transport]]
[[Category: Vesicle transport]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:42:41 2008''
 

Current revision

The crystal structure of the bet3-trs31-sedlin complex.

PDB ID 2j3w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j3w"
Personal tools