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2jax
From Proteopedia
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| - | [[Image:2jax.png|left|200px]] | ||
| - | + | ==Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis== | |
| - | + | <StructureSection load='2jax' size='340' side='right'caption='[[2jax]], [[Resolution|resolution]] 3.22Å' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2jax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[2jax]] is a 1 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jax OCA], [https://pdbe.org/2jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jax RCSB], [https://www.ebi.ac.uk/pdbsum/2jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jax ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Bartunik, H D | + | == Function == |
| - | [[Category: Bourenkov, G | + | [[https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU]] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function. |
| - | [[Category: Oberschall, A | + | == Evolutionary Conservation == |
| - | [[Category: Strizhov, N | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jax_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jax ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Myctu]] | ||
| + | [[Category: Bartunik, H D]] | ||
| + | [[Category: Bourenkov, G]] | ||
| + | [[Category: Oberschall, A]] | ||
| + | [[Category: Strizhov, N]] | ||
[[Category: Atp binding]] | [[Category: Atp binding]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Universal stress protein]] | [[Category: Universal stress protein]] | ||
[[Category: Usp]] | [[Category: Usp]] | ||
Current revision
Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis
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