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3bxf

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==Crystal structure of effector binding domain of central glycolytic gene regulator (CggR) from Bacillus subtilis in complex with effector fructose-1,6-bisphosphate==
==Crystal structure of effector binding domain of central glycolytic gene regulator (CggR) from Bacillus subtilis in complex with effector fructose-1,6-bisphosphate==
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<StructureSection load='3bxf' size='340' side='right' caption='[[3bxf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3bxf' size='340' side='right'caption='[[3bxf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bxf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BXF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bxf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2okg|2okg]], [[3bxe|3bxe]], [[3bxg|3bxg]], [[3bxh|3bxh]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2okg|2okg]], [[3bxe|3bxe]], [[3bxg|3bxg]], [[3bxh|3bxh]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cggR, yvbQ, BSU33950 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cggR, yvbQ, BSU33950 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxf OCA], [http://pdbe.org/3bxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bxf RCSB], [http://www.ebi.ac.uk/pdbsum/3bxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxf OCA], [https://pdbe.org/3bxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxf RCSB], [https://www.ebi.ac.uk/pdbsum/3bxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CGGR_BACSU CGGR_BACSU]] In the absence of glucose, represses the transcription of the gapA operon, which encodes five key glycolytic enzymes. Binds specifically to the cggR-gapA promoter region and blocks the progression of the RNA polymerase, leading to the arrest of the transcription.<ref>PMID:10799476</ref> <ref>PMID:12622823</ref> <ref>PMID:20462860</ref>
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[[https://www.uniprot.org/uniprot/CGGR_BACSU CGGR_BACSU]] In the absence of glucose, represses the transcription of the gapA operon, which encodes five key glycolytic enzymes. Binds specifically to the cggR-gapA promoter region and blocks the progression of the RNA polymerase, leading to the arrest of the transcription.<ref>PMID:10799476</ref> <ref>PMID:12622823</ref> <ref>PMID:20462860</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Large Structures]]
[[Category: Otwinowski, Z]]
[[Category: Otwinowski, Z]]
[[Category: Rezacova, P]]
[[Category: Rezacova, P]]

Revision as of 08:28, 19 January 2022

Crystal structure of effector binding domain of central glycolytic gene regulator (CggR) from Bacillus subtilis in complex with effector fructose-1,6-bisphosphate

PDB ID 3bxf

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