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3bxl
From Proteopedia
(Difference between revisions)
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==Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex== | ==Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex== | ||
| - | <StructureSection load='3bxl' size='340' side='right' caption='[[3bxl]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3bxl' size='340' side='right'caption='[[3bxl]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3bxl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3bxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bxk|3bxk]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bxk|3bxk]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Calm1, Calm, Cam, Cam1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Calm1, Calm, Cam, Cam1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxl OCA], [https://pdbe.org/3bxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxl RCSB], [https://www.ebi.ac.uk/pdbsum/3bxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxl ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CAC1E_RAT CAC1E_RAT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Calmodulin|Calmodulin]] | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] |
| - | *[[Ion channels|Ion channels]] | + | *[[Ion channels 3D structures|Ion channels 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kooi, C W.Vander]] | [[Category: Kooi, C W.Vander]] | ||
[[Category: Leahy, D J]] | [[Category: Leahy, D J]] | ||
Revision as of 08:28, 19 January 2022
Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex
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Categories: Buffalo rat | Large Structures | Kooi, C W.Vander | Leahy, D J | Mori, M X | Yue, D T | Acetylation | Calcium channel | Calcium transport | Calcium-dependent | Calmodulin | Facillitation | Glycoprotein | Inactivation | Ion channel | Ion transport | Ionic channel | Iq domain | Membrane | Membrane protein | Methylation | Phosphoprotein | Robetta | Signaling protein | Simulation | Transmembrane | Transport | Ubl conjugation | Voltage-gated | Voltage-gated channel
