3c30
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3c30 is ON HOLD until Paper Publication Authors: Slama, B., Hendrickson, W. Description: Crystal structure of the Vibrio Cholerae LuxQ periplasmic ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Vibrio Cholerae LuxQ periplasmic domain (SeMet)== | |
| - | + | <StructureSection load='3c30' size='340' side='right'caption='[[3c30]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3c30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C30 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c38|3c38]]</div></td></tr> | |
| - | '' | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">luxQ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c30 OCA], [https://pdbe.org/3c30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c30 RCSB], [https://www.ebi.ac.uk/pdbsum/3c30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c30 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LUXQ_VIBCH LUXQ_VIBCH]] At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/3c30_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c30 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae]] | ||
| + | [[Category: Hendrickson, W]] | ||
| + | [[Category: Slama, B]] | ||
| + | [[Category: 2-component system]] | ||
| + | [[Category: Histidine kinase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inner membrane]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Protein phosphatase]] | ||
| + | [[Category: Quorum sensing]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transmembrane]] | ||
| + | [[Category: Two-component regulatory system]] | ||
Current revision
Crystal structure of the Vibrio Cholerae LuxQ periplasmic domain (SeMet)
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