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3c9q
From Proteopedia
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| - | [[Image:3c9q.png|left|200px]] | ||
| - | + | ==Crystal structure of the uncharacterized human protein C8orf32 with bound peptide== | |
| - | + | <StructureSection load='3c9q' size='340' side='right'caption='[[3c9q]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3c9q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C9Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[3c9q]] is a 2 chain structure with sequence from [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C8orf32 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c9q OCA], [https://pdbe.org/3c9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c9q RCSB], [https://www.ebi.ac.uk/pdbsum/3c9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c9q ProSAT], [https://www.topsan.org/Proteins/CESG/3c9q TOPSAN]</span></td></tr> |
| - | [[Category: Bingman, C A | + | </table> |
| - | [[Category: Bitto, E | + | == Function == |
| - | [[Category: | + | [[https://www.uniprot.org/uniprot/NTAQ1_HUMAN NTAQ1_HUMAN]] Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). |
| - | [[Category: McCoy, J G | + | == Evolutionary Conservation == |
| - | [[Category: Phillips, G N | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: Wesenberg, G E | + | Check<jmol> |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c9q_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c9q ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bingman, C A]] | ||
| + | [[Category: Bitto, E]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: McCoy, J G]] | ||
| + | [[Category: Phillips, G N]] | ||
| + | [[Category: Wesenberg, G E]] | ||
[[Category: Candidate gene important in the pathogenesis of t-cell prolymphocytic leukemia]] | [[Category: Candidate gene important in the pathogenesis of t-cell prolymphocytic leukemia]] | ||
| - | [[Category: Center for eukaryotic structural genomic]] | ||
[[Category: Cesg]] | [[Category: Cesg]] | ||
[[Category: Gene associated with cre-pathway activation]] | [[Category: Gene associated with cre-pathway activation]] | ||
[[Category: Medically relevant]] | [[Category: Medically relevant]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Putative involvement in human inherited ataxias and disorders of purkinje cell degeneration]] | [[Category: Putative involvement in human inherited ataxias and disorders of purkinje cell degeneration]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Current revision
Crystal structure of the uncharacterized human protein C8orf32 with bound peptide
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Categories: Human | Large Structures | Bingman, C A | Bitto, E | Structural genomic | McCoy, J G | Phillips, G N | Wesenberg, G E | Candidate gene important in the pathogenesis of t-cell prolymphocytic leukemia | Cesg | Gene associated with cre-pathway activation | Medically relevant | PSI, Protein structure initiative | Putative involvement in human inherited ataxias and disorders of purkinje cell degeneration | Unknown function
