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3ceq
From Proteopedia
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==The TPR domain of Human Kinesin Light Chain 2 (hKLC2)== | ==The TPR domain of Human Kinesin Light Chain 2 (hKLC2)== | ||
| - | <StructureSection load='3ceq' size='340' side='right' caption='[[3ceq]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='3ceq' size='340' side='right'caption='[[3ceq]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ceq]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ceq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CEQ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLC2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ceq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ceq OCA], [https://pdbe.org/3ceq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ceq RCSB], [https://www.ebi.ac.uk/pdbsum/3ceq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ceq ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/KLC2_HUMAN KLC2_HUMAN]] Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3ceq_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3ceq_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ceq ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Kinesin|Kinesin]] | + | *[[Kinesin 3D Structures|Kinesin 3D Structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev, A | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bochkarev, A]] |
| - | [[Category: Edwards, A M | + | [[Category: Bountra, C]] |
| - | [[Category: MacKenzie, F | + | [[Category: Edwards, A M]] |
| - | [[Category: Park, H | + | [[Category: MacKenzie, F]] |
| - | [[Category: | + | [[Category: Park, H]] |
| - | [[Category: Shen, Y | + | [[Category: Structural genomic]] |
| - | [[Category: Weigelt, J | + | [[Category: Shen, Y]] |
| - | [[Category: Zhu, H | + | [[Category: Weigelt, J]] |
| + | [[Category: Zhu, H]] | ||
[[Category: Helix turn helix]] | [[Category: Helix turn helix]] | ||
[[Category: Microtubule]] | [[Category: Microtubule]] | ||
| Line 37: | Line 41: | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Tpr repeat]] | [[Category: Tpr repeat]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Current revision
The TPR domain of Human Kinesin Light Chain 2 (hKLC2)
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Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Bountra, C | Edwards, A M | MacKenzie, F | Park, H | Structural genomic | Shen, Y | Weigelt, J | Zhu, H | Helix turn helix | Microtubule | Motor protein | Phosphoprotein | Sgc | Tpr repeat | Transport protein
