3ciy
From Proteopedia
(Difference between revisions)
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==Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA== | ==Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA== | ||
| - | <StructureSection load='3ciy' size='340' side='right' caption='[[3ciy]], [[Resolution|resolution]] 3.41Å' scene=''> | + | <StructureSection load='3ciy' size='340' side='right'caption='[[3ciy]], [[Resolution|resolution]] 3.41Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ciy]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ciy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CIY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cig|3cig]], [[2a0z|2a0z]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cig|3cig]], [[2a0z|2a0z]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr3 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ciy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ciy OCA], [https://pdbe.org/3ciy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ciy RCSB], [https://www.ebi.ac.uk/pdbsum/3ciy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ciy ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TLR3_MOUSE TLR3_MOUSE]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:14993594</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Leucine-rich repeat|Leucine-rich repeat]] | *[[Leucine-rich repeat|Leucine-rich repeat]] | ||
| + | *[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | ||
*[[Toll-like Receptors|Toll-like Receptors]] | *[[Toll-like Receptors|Toll-like Receptors]] | ||
| - | *[[User:Wayne Decatur/NASCE2011|User:Wayne Decatur/NASCE2011]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
Revision as of 07:57, 27 January 2022
Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA
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Categories: Large Structures | Lk3 transgenic mice | RCSB PDB Molecule of the Month | Toll-like Receptors | Botos, I | Davies, D R | Leonard, J N | Liu, L | Segal, D M | Shiloach, J | Wang, Y | Dsrna | Glycoprotein | Immune response | Immune system-rna complex | Inflammatory response | Innate immunity | Leucine rich repeat | Leucine-rich repeat | Lrr | Membrane | Protein-dsrna complex | Receptor | Tlr | Transmembrane
