3ckw

<StructureSection load='3ckw' size='340' side='right' caption='[[3ckw]], [[Resolution|resolution]] 1.96&Aring;' scene=''>

<table><tr><td colspan='2'>[[3ckw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CKW FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckw OCA], [http://pdbe.org/3ckw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ckw RCSB], [http://www.ebi.ac.uk/pdbsum/3ckw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckw ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3ckw TOPSAN]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN]] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>

*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]

[[Category: Human]]

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Antonysamy, S S]]

[[Category: Buchanan, S]]

[[Category: Burley, S K]]

[[Category: Chau, F]]

[[Category: Feil, I]]

[[Category: Structural genomic]]

[[Category: Sauder, J M]]

[[Category: Wu, L]]

[[Category: Transferase]]