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2kmo

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==Solution structure of native Leech-derived tryptase inhibitor, LDTI==
==Solution structure of native Leech-derived tryptase inhibitor, LDTI==
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<StructureSection load='2kmo' size='340' side='right' caption='[[2kmo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kmo' size='340' side='right'caption='[[2kmo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hirme Hirme]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KMO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kmo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirme Hirme]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMO FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kmp|2kmp]], [[2kmq|2kmq]], [[2kmr|2kmr]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kmp|2kmp]], [[2kmq|2kmq]], [[2kmr|2kmr]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmo OCA], [http://pdbe.org/2kmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kmo RCSB], [http://www.ebi.ac.uk/pdbsum/2kmo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmo OCA], [https://pdbe.org/2kmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmo RCSB], [https://www.ebi.ac.uk/pdbsum/2kmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LDTI_HIRME LDTI_HIRME]] Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms.
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[[https://www.uniprot.org/uniprot/LDTI_HIRME LDTI_HIRME]] Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmo_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmo_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kmo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</StructureSection>
</StructureSection>
[[Category: Hirme]]
[[Category: Hirme]]
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[[Category: Large Structures]]
[[Category: Pantoja-Uceda, D]]
[[Category: Pantoja-Uceda, D]]
[[Category: Santoro, J]]
[[Category: Santoro, J]]

Current revision

Solution structure of native Leech-derived tryptase inhibitor, LDTI

PDB ID 2kmo

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