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2knj

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==NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus==
==NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus==
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<StructureSection load='2knj' size='340' side='right' caption='[[2knj]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2knj' size='340' side='right'caption='[[2knj]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2knj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Boophilus_microplus Boophilus microplus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2knj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Boophilus_microplus Boophilus microplus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knj OCA], [http://pdbe.org/2knj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2knj RCSB], [http://www.ebi.ac.uk/pdbsum/2knj PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knj OCA], [https://pdbe.org/2knj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knj RCSB], [https://www.ebi.ac.uk/pdbsum/2knj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPSIN_RHIMP MPSIN_RHIMP]] Has bacteriostatic activity against the Gram-positive bacterium M.luteus, but not against Gram-negative bacterium E.coli SBS363. Has fungistatic activity against C.neoformans, but not C.albicans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus.<ref>PMID:14642886</ref>
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[[https://www.uniprot.org/uniprot/MPSIN_RHIMP MPSIN_RHIMP]] Has bacteriostatic activity against the Gram-positive bacterium M.luteus, but not against Gram-negative bacterium E.coli SBS363. Has fungistatic activity against C.neoformans, but not C.albicans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus.<ref>PMID:14642886</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/2knj_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/2knj_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2knj ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</StructureSection>
</StructureSection>
[[Category: Boophilus microplus]]
[[Category: Boophilus microplus]]
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[[Category: Large Structures]]
[[Category: Daffre, S]]
[[Category: Daffre, S]]
[[Category: Pires, J R]]
[[Category: Pires, J R]]

Current revision

NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus

PDB ID 2knj

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