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2knj
From Proteopedia
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==NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus== | ==NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus== | ||
| - | <StructureSection load='2knj' size='340' side='right' caption='[[2knj]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='2knj' size='340' side='right'caption='[[2knj]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2knj]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2knj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Boophilus_microplus Boophilus microplus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knj OCA], [https://pdbe.org/2knj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knj RCSB], [https://www.ebi.ac.uk/pdbsum/2knj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MPSIN_RHIMP MPSIN_RHIMP]] Has bacteriostatic activity against the Gram-positive bacterium M.luteus, but not against Gram-negative bacterium E.coli SBS363. Has fungistatic activity against C.neoformans, but not C.albicans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus.<ref>PMID:14642886</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/2knj_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/2knj_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Boophilus microplus]] | [[Category: Boophilus microplus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Daffre, S]] | [[Category: Daffre, S]] | ||
[[Category: Pires, J R]] | [[Category: Pires, J R]] | ||
Current revision
NMR structure of microplusin a antimicrobial peptide from Rhipicephalus (Boophilus) microplus
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