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3dcy
From Proteopedia
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| - | [[Image:3dcy.png|left|200px]] | ||
| - | + | ==Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.== | |
| - | + | <StructureSection load='3dcy' size='340' side='right'caption='[[3dcy]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3dcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DCY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[3dcy]] is a 1 chain structure with sequence from [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C12orf5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dcy OCA], [https://pdbe.org/3dcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dcy RCSB], [https://www.ebi.ac.uk/pdbsum/3dcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dcy ProSAT], [https://www.topsan.org/Proteins/CESG/3dcy TOPSAN]</span></td></tr> |
| - | [[Category: Bingman, C A | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: McCoy, J G | + | [[https://www.uniprot.org/uniprot/TIGAR_HUMAN TIGAR_HUMAN]] Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.<ref>PMID:16839880</ref> |
| - | [[Category: Phillips, G N | + | == Evolutionary Conservation == |
| - | [[Category: Wesenberg, G E | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/3dcy_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dcy ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bingman, C A]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: McCoy, J G]] | ||
| + | [[Category: Phillips, G N]] | ||
| + | [[Category: Wesenberg, G E]] | ||
[[Category: Apoptosis regulator]] | [[Category: Apoptosis regulator]] | ||
[[Category: C12orf5]] | [[Category: C12orf5]] | ||
[[Category: Casp target]] | [[Category: Casp target]] | ||
| - | [[Category: Center for eukaryotic structural genomic]] | ||
[[Category: Cesg]] | [[Category: Cesg]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Omim 610775]] | [[Category: Omim 610775]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
[[Category: Tigar]] | [[Category: Tigar]] | ||
[[Category: Tp53-induced glycolysis and apoptosis regulator]] | [[Category: Tp53-induced glycolysis and apoptosis regulator]] | ||
Current revision
Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
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Categories: Human | Large Structures | Bingman, C A | Structural genomic | McCoy, J G | Phillips, G N | Wesenberg, G E | Apoptosis regulator | C12orf5 | Casp target | Cesg | Isomerase | Omim 610775 | Phosphoprotein | PSI, Protein structure initiative | Tigar | Tp53-induced glycolysis and apoptosis regulator
