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3dws
From Proteopedia
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| - | [[Image:3dws.png|left|200px]] | ||
| - | + | ==Leishmania major Coproporphyrinogen III Oxidase with bound ligand== | |
| - | + | <StructureSection load='3dws' size='340' side='right'caption='[[3dws]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3dws]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FIC:5-FLUOROINDOLE-2-CARBOXYLIC+ACID'>FIC</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qt8|2qt8]], [[3dwr|3dwr]], [[1vju|1vju]]</div></td></tr> | |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMAJ006828, LmjF06.1270 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coproporphyrinogen_oxidase Coproporphyrinogen oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.3 1.3.3.3] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dws OCA], [https://pdbe.org/3dws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dws RCSB], [https://www.ebi.ac.uk/pdbsum/3dws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dws ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | == | + | == Function == |
| - | [[3dws]] is a 2 chain structure with sequence from [ | + | [[https://www.uniprot.org/uniprot/HEM6_LEIMA HEM6_LEIMA]] Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).[HAMAP-Rule:MF_00333] |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dws_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dws ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Coproporphyrinogen oxidase]] | [[Category: Coproporphyrinogen oxidase]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Merritt, E A | + | [[Category: Leima]] |
| - | [[Category: | + | [[Category: Merritt, E A]] |
| - | [[Category: Trong, I Le | + | [[Category: Structural genomic]] |
| + | [[Category: Trong, I Le]] | ||
[[Category: Fragment cocktail]] | [[Category: Fragment cocktail]] | ||
[[Category: Heme biosynthesis]] | [[Category: Heme biosynthesis]] | ||
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[[Category: Porphyrin biosynthesis]] | [[Category: Porphyrin biosynthesis]] | ||
[[Category: Sgpp]] | [[Category: Sgpp]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics of pathogenic protozoa consortium]] | ||
Current revision
Leishmania major Coproporphyrinogen III Oxidase with bound ligand
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