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3dxr
From Proteopedia
(Difference between revisions)
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==Crystal structure of the yeast inter-membrane space chaperone assembly TIM9.10== | ==Crystal structure of the yeast inter-membrane space chaperone assembly TIM9.10== | ||
| - | <StructureSection load='3dxr' size='340' side='right' caption='[[3dxr]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3dxr' size='340' side='right'caption='[[3dxr]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3dxr]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3dxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXR FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bsk|2bsk]], [[3cjh|3cjh]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bsk|2bsk]], [[3cjh|3cjh]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIM9 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIM9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), MRS11, TIM10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxr OCA], [https://pdbe.org/3dxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxr RCSB], [https://www.ebi.ac.uk/pdbsum/3dxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TIM9_YEAST TIM9_YEAST]] Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role.<ref>PMID:10369662</ref> <ref>PMID:10995434</ref> <ref>PMID:11483513</ref> <ref>PMID:11509656</ref> <ref>PMID:12138093</ref> <ref>PMID:12391147</ref> <ref>PMID:14978039</ref> <ref>PMID:16039669</ref> <ref>PMID:9822593</ref> <ref>PMID:9889188</ref> [[https://www.uniprot.org/uniprot/TIM10_YEAST TIM10_YEAST]] Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.<ref>PMID:10369662</ref> <ref>PMID:10995434</ref> <ref>PMID:11483513</ref> <ref>PMID:11509656</ref> <ref>PMID:12138093</ref> <ref>PMID:12391147</ref> <ref>PMID:12637749</ref> <ref>PMID:14978039</ref> <ref>PMID:16039669</ref> <ref>PMID:8955274</ref> <ref>PMID:9430585</ref> <ref>PMID:9822593</ref> <ref>PMID:9889188</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxr_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxr_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Atcc 18824]] | [[Category: Atcc 18824]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gulbis, J M]] | [[Category: Gulbis, J M]] | ||
[[Category: Webb, C T]] | [[Category: Webb, C T]] | ||
Revision as of 08:10, 9 February 2022
Crystal structure of the yeast inter-membrane space chaperone assembly TIM9.10
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