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3ecq

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Current revision (11:46, 16 February 2022) (edit) (undo)
 
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==Endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae: SeMet structure==
==Endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae: SeMet structure==
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<StructureSection load='3ecq' size='340' side='right' caption='[[3ecq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3ecq' size='340' side='right'caption='[[3ecq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ecq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ECQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ecq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ECQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ECQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spr0328 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spr0328 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-alpha-N-acetylgalactosaminidase Endo-alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.97 3.2.1.97] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Endo-alpha-N-acetylgalactosaminidase Endo-alpha-N-acetylgalactosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.97 3.2.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ecq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ecq OCA], [http://pdbe.org/3ecq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ecq RCSB], [http://www.ebi.ac.uk/pdbsum/3ecq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ecq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ecq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ecq OCA], [https://pdbe.org/3ecq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ecq RCSB], [https://www.ebi.ac.uk/pdbsum/3ecq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ecq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GH101_STRR6 GH101_STRR6]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors.<ref>PMID:18784084</ref> <ref>PMID:19788271</ref> <ref>PMID:21877</ref>
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[[https://www.uniprot.org/uniprot/GH101_STRR6 GH101_STRR6]] Is involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) from extracellular host glycoproteins. Is representative of a broadly important class of virulence factors.<ref>PMID:18784084</ref> <ref>PMID:19788271</ref> <ref>PMID:21877</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Endo-alpha-N-acetylgalactosaminidase]]
[[Category: Endo-alpha-N-acetylgalactosaminidase]]
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[[Category: Large Structures]]
[[Category: Strr6]]
[[Category: Strr6]]
[[Category: Caines, M E.C]]
[[Category: Caines, M E.C]]

Current revision

Endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae: SeMet structure

PDB ID 3ecq

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