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3elb
From Proteopedia
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| - | [[Image:3elb.png|left|200px]] | ||
| - | + | ==Human CTP: Phosphoethanolamine Cytidylyltransferase in complex with CMP== | |
| - | + | <StructureSection load='3elb' size='340' side='right'caption='[[3elb]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3elb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ELB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[3elb]] is a 1 chain structure with sequence from [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PCYT2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ethanolamine-phosphate_cytidylyltransferase Ethanolamine-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.14 2.7.7.14] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3elb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3elb OCA], [https://pdbe.org/3elb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3elb RCSB], [https://www.ebi.ac.uk/pdbsum/3elb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3elb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PCY2_HUMAN PCY2_HUMAN]] Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3elb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3elb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ethanolamine-phosphate cytidylyltransferase]] | [[Category: Ethanolamine-phosphate cytidylyltransferase]] | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Andersson, J | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Andersson, J]] |
| - | [[Category: Berg, S Van Den | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Berglund, H | + | [[Category: Berg, S Van Den]] |
| - | [[Category: Bountra, C | + | [[Category: Berglund, H]] |
| - | [[Category: Collins, R | + | [[Category: Bountra, C]] |
| - | [[Category: Dahlgren, L G | + | [[Category: Collins, R]] |
| - | [[Category: Edwards, A M | + | [[Category: Dahlgren, L G]] |
| - | [[Category: Flodin, S | + | [[Category: Edwards, A M]] |
| - | [[Category: Flores, A | + | [[Category: Flodin, S]] |
| - | [[Category: Graslund, S | + | [[Category: Flores, A]] |
| - | [[Category: Hammarstrom, M | + | [[Category: Graslund, S]] |
| - | [[Category: Johansson, A | + | [[Category: Hammarstrom, M]] |
| - | [[Category: Johansson, I | + | [[Category: Johansson, A]] |
| - | [[Category: Karlberg, T | + | [[Category: Johansson, I]] |
| - | [[Category: Kotenyova, T | + | [[Category: Karlberg, T]] |
| - | [[Category: Lehtio, L | + | [[Category: Kotenyova, T]] |
| - | [[Category: Moche, M | + | [[Category: Lehtio, L]] |
| - | [[Category: Nilsson, M E | + | [[Category: Moche, M]] |
| - | [[Category: Nordlund, P | + | [[Category: Nilsson, M E]] |
| - | [[Category: Nyman, T | + | [[Category: Nordlund, P]] |
| - | [[Category: Persson, C | + | [[Category: Nyman, T]] |
| - | [[Category: | + | [[Category: Persson, C]] |
| - | [[Category: Sagemark, J | + | [[Category: Structural genomic]] |
| - | [[Category: Schuler, H | + | [[Category: Sagemark, J]] |
| - | [[Category: Thorsell, A G | + | [[Category: Schuler, H]] |
| - | [[Category: Tresaugues, L | + | [[Category: Thorsell, A G]] |
| - | [[Category: Weigelt, J | + | [[Category: Tresaugues, L]] |
| - | [[Category: Welin, M | + | [[Category: Weigelt, J]] |
| - | [[Category: Wikstrom, M | + | [[Category: Welin, M]] |
| - | [[Category: Wisniewska, M | + | [[Category: Wikstrom, M]] |
| + | [[Category: Wisniewska, M]] | ||
[[Category: Cmp]] | [[Category: Cmp]] | ||
[[Category: Ctp]] | [[Category: Ctp]] | ||
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[[Category: Phospholipid biosynthesis]] | [[Category: Phospholipid biosynthesis]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Current revision
Human CTP: Phosphoethanolamine Cytidylyltransferase in complex with CMP
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Categories: Ethanolamine-phosphate cytidylyltransferase | Human | Large Structures | Andersson, J | Arrowsmith, C H | Berg, S Van Den | Berglund, H | Bountra, C | Collins, R | Dahlgren, L G | Edwards, A M | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, A | Johansson, I | Karlberg, T | Kotenyova, T | Lehtio, L | Moche, M | Nilsson, M E | Nordlund, P | Nyman, T | Persson, C | Structural genomic | Sagemark, J | Schuler, H | Thorsell, A G | Tresaugues, L | Weigelt, J | Welin, M | Wikstrom, M | Wisniewska, M | Cmp | Ctp | Cytidylyltransferase | Kennedy pathway | Nucleotidyltransferase | Phosphoethanolamine | Phospholipid biosynthesis | Sgc | Transferase
