1gg3

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[[Image:1gg3.gif|left|200px]]
[[Image:1gg3.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1gg3| PDB=1gg3 | SCENE= }}
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|RELATEDENTRY=[[1ef1|1ef1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg3 OCA], [http://www.ebi.ac.uk/pdbsum/1gg3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gg3 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN'''
'''CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN'''
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[[Category: 30kd]]
[[Category: 30kd]]
[[Category: 4 1r]]
[[Category: 4 1r]]
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[[Category: blood]]
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[[Category: Blood]]
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[[Category: calmodulin]]
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[[Category: Calmodulin]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: n-terminal domain]]
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[[Category: N-terminal domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:31:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:43:14 2008''
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Revision as of 14:31, 2 May 2008

Image:1gg3.gif

Template:STRUCTURE 1gg3

CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN


Overview

The crystal structure of the core domain (N-terminal 30 kDa domain) of cytoskeletal protein 4.1R has been determined and shows a cloverleaf-like architecture. Each lobe of the cloverleaf contains a specific binding site for either band 3, glycophorin C/D or p55. At a central region of the molecule near where the three lobes are joined are two separate calmodulin (CaM) binding regions. One of these is composed primarily of an alpha-helix and is Ca 2+ insensitive; the other takes the form of an extended structure and its binding with CaM is dramatically enhanced by the presence of Ca 2+, resulting in the weakening of protein 4.1R binding to its target proteins. This novel architecture, in which the three lobes bind with three membrane associated proteins, and the location of calmodulin binding sites provide insight into how the protein 4.1R core domain interacts with membrane proteins and dynamically regulates cell shape in response to changes in intracellular Ca2+ levels.

About this Structure

1GG3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization., Han BG, Nunomura W, Takakuwa Y, Mohandas N, Jap BK, Nat Struct Biol. 2000 Oct;7(10):871-5. PMID:11017195 Page seeded by OCA on Fri May 2 17:31:07 2008

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