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3eoy
From Proteopedia
(Difference between revisions)
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==Structure of Reovirus sigma1 in Complex with Its Receptor Junctional Adhesion Molecule-A== | ==Structure of Reovirus sigma1 in Complex with Its Receptor Junctional Adhesion Molecule-A== | ||
| - | <StructureSection load='3eoy' size='340' side='right' caption='[[3eoy]], [[Resolution|resolution]] 3.40Å' scene=''> | + | <StructureSection load='3eoy' size='340' side='right'caption='[[3eoy]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3eoy]] is a 12 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3eoy]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_strain_dearing Mammalian orthoreovirus 3 strain dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOY FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oj5|2oj5]], [[1kke|1kke]], [[1nbq|1nbq]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2oj5|2oj5]], [[1kke|1kke]], [[1nbq|1nbq]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian Orthoreovirus 3 strain Dearing])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoy OCA], [https://pdbe.org/3eoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eoy RCSB], [https://www.ebi.ac.uk/pdbsum/3eoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoy ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. [[https://www.uniprot.org/uniprot/JAM1_HUMAN JAM1_HUMAN]] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoy_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoy_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Hemagglutinin|Hemagglutinin]] | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] |
| + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mammalian orthoreovirus 3 strain dearing]] | [[Category: Mammalian orthoreovirus 3 strain dearing]] | ||
[[Category: Dermody, T S]] | [[Category: Dermody, T S]] | ||
Revision as of 09:12, 23 February 2022
Structure of Reovirus sigma1 in Complex with Its Receptor Junctional Adhesion Molecule-A
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Categories: Human | Large Structures | Mammalian orthoreovirus 3 strain dearing | Dermody, T S | Guglielmi, K M | Kirchner, E | Stehle, T | Beta-barrel | Beta-spiral repeat | Greek key motif | Immunoglobulin superfamily | Protein complex | Trimer | Viral protein-cell adhesion complex | Virus receptor complex
