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3epv

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Current revision (09:13, 23 February 2022) (edit) (undo)
 
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==X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms==
==X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms==
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<StructureSection load='3epv' size='340' side='right' caption='[[3epv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='3epv' size='340' side='right'caption='[[3epv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [http://pdbe.org/3epv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [http://www.ebi.ac.uk/pdbsum/3epv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3epv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [https://pdbe.org/3epv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [https://www.ebi.ac.uk/pdbsum/3epv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CNRR_RALME CNRR_RALME]] CnrH alone is able to activate cnr expression, while both CnrY and CrnR (CnrX) are needed for nickel induction of CnrH (PubMed:10671463). Has been suggested (PubMed:10671464) to bind nickel.
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[[https://www.uniprot.org/uniprot/CNRR_RALME CNRR_RALME]] CnrH alone is able to activate cnr expression, while both CnrY and CrnR (CnrX) are needed for nickel induction of CnrH (PubMed:10671463). Has been suggested (PubMed:10671464) to bind nickel.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Cupmc]]
[[Category: Cupmc]]
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[[Category: Large Structures]]
[[Category: Coves, J]]
[[Category: Coves, J]]
[[Category: Gambarelli, S]]
[[Category: Gambarelli, S]]

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X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms

PDB ID 3epv

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