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1um7
From Proteopedia
(Difference between revisions)
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<StructureSection load='1um7' size='340' side='right'caption='[[1um7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1um7' size='340' side='right'caption='[[1um7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1um7]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1um7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UM7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA KIAA1232 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA KIAA1232 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1um7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1um7 OCA], [https://pdbe.org/1um7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1um7 RCSB], [https://www.ebi.ac.uk/pdbsum/1um7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1um7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1um7 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 06:46, 2 March 2022
Solution structure of the third PDZ domain of synapse-associated protein 102
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