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1x3h

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<StructureSection load='1x3h' size='340' side='right'caption='[[1x3h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1x3h' size='340' side='right'caption='[[1x3h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x3h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X3H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X3H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LPXN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LPXN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3h OCA], [http://pdbe.org/1x3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x3h RCSB], [http://www.ebi.ac.uk/pdbsum/1x3h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x3h ProSAT], [http://www.topsan.org/Proteins/RSGI/1x3h TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3h OCA], [https://pdbe.org/1x3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x3h RCSB], [https://www.ebi.ac.uk/pdbsum/1x3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x3h ProSAT], [https://www.topsan.org/Proteins/RSGI/1x3h TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPXN_HUMAN LPXN_HUMAN]] Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.<ref>PMID:17640867</ref> <ref>PMID:18497331</ref> <ref>PMID:18451096</ref> <ref>PMID:20543562</ref>
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[[https://www.uniprot.org/uniprot/LPXN_HUMAN LPXN_HUMAN]] Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.<ref>PMID:17640867</ref> <ref>PMID:18497331</ref> <ref>PMID:18451096</ref> <ref>PMID:20543562</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 07:03, 2 March 2022

Solution structure of the LIM domain of human Leupaxin

PDB ID 1x3h

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