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5scv
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889== | ==Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889== | ||
| - | <StructureSection load='5scv' size='340' side='right'caption='[[5scv]]' scene=''> | + | <StructureSection load='5scv' size='340' side='right'caption='[[5scv]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SCV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5scv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SCV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5scv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5scv OCA], [https://pdbe.org/5scv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5scv RCSB], [https://www.ebi.ac.uk/pdbsum/5scv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5scv ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=H4U:6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine'>H4U</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5scv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5scv OCA], [https://pdbe.org/5scv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5scv RCSB], [https://www.ebi.ac.uk/pdbsum/5scv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5scv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Dihydrofolate reductase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Dhfr]] | ||
| + | [[Category: Folate]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Nadp]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: Ssgcid]] | ||
Revision as of 07:20, 2 March 2022
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889
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