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3fb2
From Proteopedia
(Difference between revisions)
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==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | ==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | ||
| - | <StructureSection load='3fb2' size='340' side='right' caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3fb2' size='340' side='right'caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB2 FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u5p|1u5p]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u5p|1u5p]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [https://pdbe.org/3fb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN]] West syndrome. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| + | |||
| + | ==See Also== | ||
| + | *[[Spectrin|Spectrin]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Acton, T B]] | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C]] | [[Category: Ciccosanti, C]] | ||
Revision as of 07:56, 2 March 2022
Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.
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Categories: Human | Large Structures | Acton, T B | Ciccosanti, C | Foote, E L | Hunt, J F | Janjua, H | Montelione, G T | Structural genomic | Seetharaman, J | Shastry, R | Su, M | Tong, L | Vorobiev, S M | Xiao, R | Actin capping | Actin-binding | Alternative splicing | Brain spectrin | Calcium | Calmodulin-binding | Cytoplasm | Cytoskeleton | Fordrin alpha chain | Hr5563a | Nesg | Non-erythroid alpha chain alpha-ii spectrin | Phosphoprotein | Polymorphism | PSI, Protein structure initiative | Sh3 domain | Spectrin alpha chain | Spta2 human | Sptan1 | Structural protein
