3fv5
From Proteopedia
(Difference between revisions)
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==Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor== | ==Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor== | ||
| - | <StructureSection load='3fv5' size='340' side='right' caption='[[3fv5]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3fv5' size='340' side='right'caption='[[3fv5]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fv5]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3fv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FV5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EU:1-(4-ACETYL-6-PYRIDIN-3-YL-1H-BENZIMIDAZOL-2-YL)-3-ETHYLUREA'>1EU</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EU:1-(4-ACETYL-6-PYRIDIN-3-YL-1H-BENZIMIDAZOL-2-YL)-3-ETHYLUREA'>1EU</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parE, nfxD, b3030, JW2998 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parE, nfxD, b3030, JW2998 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fv5 OCA], [https://pdbe.org/3fv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fv5 RCSB], [https://www.ebi.ac.uk/pdbsum/3fv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fv5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PARE_ECOLI PARE_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:21300644</ref> <ref>PMID:15105144</ref> <ref>PMID:20921377</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Topoisomerase|Topoisomerase]] | + | *[[Topoisomerase 3D structures|Topoisomerase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Ecoli]] | [[Category: Ecoli]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Charifson, P]] | [[Category: Charifson, P]] | ||
[[Category: LeTiran, A]] | [[Category: LeTiran, A]] | ||
Revision as of 08:12, 2 March 2022
Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor
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