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3fxy

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{{Seed}}
 
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[[Image:3fxy.jpg|left|200px]]
 
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<!--
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==Acidic Mammalian Chinase, Catalytic Domain==
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The line below this paragraph, containing "STRUCTURE_3fxy", creates the "Structure Box" on the page.
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<StructureSection load='3fxy' size='340' side='right'caption='[[3fxy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fxy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FXY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fy1|3fy1]]</div></td></tr>
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-->
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHIA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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{{STRUCTURE_3fxy| PDB=3fxy | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxy OCA], [https://pdbe.org/3fxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fxy RCSB], [https://www.ebi.ac.uk/pdbsum/3fxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fxy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CHIA_HUMAN CHIA_HUMAN]] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.<ref>PMID:11085997</ref> <ref>PMID:18824549</ref> <ref>PMID:19342690</ref> <ref>PMID:19435888</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fxy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Acidic mammalian chitinase (AMCase) is a mammalian chitinase that has been implicated in allergic asthma. One of only two active mammalian chinases, AMCase, is distinguished from other chitinases by several unique features. Here, we present the novel structure of the AMCase catalytic domain, both in the apo form and in complex with the inhibitor methylallosamidin, determined to high resolution by X-ray crystallography. These results provide a structural basis for understanding some of the unique characteristics of this enzyme, including the low pH optimum and the preference for the beta-anomer of the substrate. A triad of polar residues in the second-shell is found to modulate the highly conserved chitinase active site. As a novel target for asthma therapy, structural details of AMCase activity will help guide the future design of specific and potent AMCase inhibitors.
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===Acidic Mammalian Chinase, Catalytic Domain===
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Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.,Olland AM, Strand J, Presman E, Czerwinski R, Joseph-McCarthy D, Krykbaev R, Schlingmann G, Chopra R, Lin L, Fleming M, Kriz R, Stahl M, Somers W, Fitz L, Mosyak L Protein Sci. 2009 Mar;18(3):569-78. PMID:19241384<ref>PMID:19241384</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fxy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19241384}}, adds the Publication Abstract to the page
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*[[Chitinase 3D structures|Chitinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19241384 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_19241384}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3FXY is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXY OCA].
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==Reference==
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<ref group="xtra">PMID:19241384</ref><references group="xtra"/>
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[[Category: Chitinase]]
[[Category: Chitinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Olland, A M.]]
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[[Category: Large Structures]]
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[[Category: Olland, A M]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Asthma]]
[[Category: Asthma]]
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[[Category: Chitin degradation]]
[[Category: Chitin degradation]]
[[Category: Chitin-binding]]
[[Category: Chitin-binding]]
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[[Category: Chitinase]]
 
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[[Category: Crystallography]]
 
[[Category: Cytoplasm]]
[[Category: Cytoplasm]]
[[Category: Glycosidase]]
[[Category: Glycosidase]]
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[[Category: Polysaccharide degradation]]
[[Category: Polysaccharide degradation]]
[[Category: Secreted]]
[[Category: Secreted]]
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[[Category: Structure]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:16:31 2009''
 

Current revision

Acidic Mammalian Chinase, Catalytic Domain

PDB ID 3fxy

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