This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3g3z
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3g3z.png|left|200px]] | ||
| - | < | + | ==The structure of NMB1585, a MarR family regulator from Neisseria meningitidis== |
| - | + | <StructureSection load='3g3z' size='340' side='right'caption='[[3g3z]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | You may | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[3g3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | -- | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMB1585 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3z OCA], [https://pdbe.org/3g3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3z RCSB], [https://www.ebi.ac.uk/pdbsum/3g3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3z ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3z_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g3z ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the MarR-family transcription factor NMB1585 from Neisseria meningitidis has been solved using data extending to a resolution of 2.1 A. Overall, the dimeric structure resembles those of other MarR proteins, with each subunit comprising a winged helix-turn-helix (wHtH) domain connected to an alpha-helical dimerization domain. The spacing of the recognition helices of the wHtH domain indicates that NMB1585 is pre-configured for DNA binding, with a putative inducer pocket that is largely occluded by the side chains of two aromatic residues (Tyr29 and Trp53). NMB1585 was shown to bind to its own promoter region in a gel-shift assay, indicating that the protein acts as an auto-repressor. | ||
| - | + | The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis.,Nichols CE, Sainsbury S, Ren J, Walter TS, Verma A, Stammers DK, Saunders NJ, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt, 3):204-9. Epub 2009 Feb 26. PMID:19255465<ref>PMID:19255465</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3g3z" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Large Structures]] |
| - | + | [[Category: Neimi]] | |
| - | + | [[Category: Nichols, C E]] | |
| - | == | + | [[Category: OPPF, Oxford Protein Production Facility]] |
| - | < | + | [[Category: Owens, R J]] |
| - | [[Category: | + | [[Category: Ren, J]] |
| - | [[Category: Nichols, C E | + | [[Category: Sainsbury, S]] |
| - | [[Category: OPPF, Oxford Protein Production Facility | + | [[Category: Saunders, N J]] |
| - | [[Category: Owens, R J | + | [[Category: Stammers, D K]] |
| - | [[Category: Ren, J | + | [[Category: Verma, A]] |
| - | [[Category: Sainsbury, S | + | [[Category: Walter, T S]] |
| - | [[Category: Saunders, N J | + | |
| - | [[Category: Stammers, D K | + | |
| - | [[Category: Verma, A | + | |
| - | [[Category: Walter, T S | + | |
[[Category: Marr]] | [[Category: Marr]] | ||
[[Category: Neisseria meningitidi]] | [[Category: Neisseria meningitidi]] | ||
| Line 39: | Line 47: | ||
[[Category: Oxford protein production facility]] | [[Category: Oxford protein production facility]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
| + | [[Category: Transcription]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:02:55 2009'' | ||
Current revision
The structure of NMB1585, a MarR family regulator from Neisseria meningitidis
| |||||||||||
Categories: Large Structures | Neimi | Nichols, C E | OPPF, Oxford Protein Production Facility | Owens, R J | Ren, J | Sainsbury, S | Saunders, N J | Stammers, D K | Verma, A | Walter, T S | Marr | Neisseria meningitidi | Oppf | Oxford protein production facility | Structural genomic | Transcription | Transcription factor
