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3g40

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Revision as of 07:55, 9 March 2022

Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter

Structural highlights

3g40 is a 1 chain structure with sequence from Atcc 35395. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	MA4506 (ATCC 35395)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride in dependence of sodium and potassium. The proteins share a conserved structural scaffold that consists of a transmembrane transport domain followed by a cytoplasmic regulatory domain. We have determined the X-ray structure of the C-terminal domain of the archaea Methanosarcina acetivorans. The structure shows a novel fold of a regulatory domain that is distantly related to universal stress proteins. The protein forms dimers in solution, which is consistent with the proposed dimeric organization of eukaryotic CCC transporters. The dimer interface observed in different crystal forms is unusual because the buried area is relatively small and hydrophilic. By using a biochemical approach we show that this interaction is preserved in solution and in the context of the full-length transporter. Our studies reveal structural insight into the CCC family and establish the oligomeric organization of this important class of transport proteins.

X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter.,Warmuth S, Zimmermann I, Dutzler R Structure. 2009 Apr 15;17(4):538-46. PMID:19368887^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Warmuth S, Zimmermann I, Dutzler R. X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter. Structure. 2009 Apr 15;17(4):538-46. PMID:19368887 doi:10.1016/j.str.2009.02.009

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3g40"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter==
-<StructureSection load='3g40' size='340' side='right' caption='[[3g40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='3g40' size='340' side='right'caption='[[3g40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3g40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35395 Atcc 35395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G40 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3g40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35395 Atcc 35395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G40 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MA4506 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2214 ATCC 35395])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MA4506 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2214 ATCC 35395])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g40 OCA], [http://pdbe.org/3g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g40 RCSB], [http://www.ebi.ac.uk/pdbsum/3g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g40 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g40 OCA], [https://pdbe.org/3g40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g40 RCSB], [https://www.ebi.ac.uk/pdbsum/3g40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g40 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 31: / Line 31: @@
 </StructureSection>
 [[Category: Atcc 35395]]
+[[Category: Large Structures]]
 [[Category: Dutzler, R]]
 [[Category: Warmuth, S]]

3g40

From Proteopedia

Revision as of 07:55, 9 March 2022

Crystal structure of the cytoplasmic domain of a prokaryotic cation chloride cotransporter

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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