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3g6t
From Proteopedia
(Difference between revisions)
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==GR gamma DNA-binding domain:FKBP5 16bp complex-34== | ==GR gamma DNA-binding domain:FKBP5 16bp complex-34== | ||
| - | <StructureSection load='3g6t' size='340' side='right' caption='[[3g6t]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3g6t' size='340' side='right'caption='[[3g6t]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3g6t]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3g6t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G6T FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fyl|3fyl]], [[3g6p|3g6p]], [[3g6q|3g6q]], [[3g6r|3g6r]], [[3g6u|3g6u]], [[3g8x|3g8x]], [[3g97|3g97]], [[3g99|3g99]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fyl|3fyl]], [[3g6p|3g6p]], [[3g6q|3g6q]], [[3g6r|3g6r]], [[3g6u|3g6u]], [[3g8x|3g8x]], [[3g97|3g97]], [[3g99|3g99]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6t OCA], [https://pdbe.org/3g6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g6t RCSB], [https://www.ebi.ac.uk/pdbsum/3g6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6t_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6t_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3g6t" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3g6t" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Meijsing, S H]] | [[Category: Meijsing, S H]] | ||
[[Category: Pufall, M A]] | [[Category: Pufall, M A]] | ||
Revision as of 07:57, 9 March 2022
GR gamma DNA-binding domain:FKBP5 16bp complex-34
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Categories: Buffalo rat | Large Structures | Meijsing, S H | Pufall, M A | Yamamoto, K R | Allostery | Alternative initiation | Chromatin regulator | Cytoplasm | Dna-binding | Glucocorticoid | Hormone | Lever arm | Lipid-binding | Metal-binding | Nucleus | Phosphoprotein | Polymorphism | Receptor | Steroid-binding | Transcription | Transcription regulation | Transcription-dna complex | Ubl conjugation | Zinc | Zinc-finger
