Methionine adenosyltransferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
<StructureSection load='1o9t' size='350' side='right' caption='The rat S-adenosylmethionine synthetase complex with methionine, phosphate, ATP (stick model), Mg+2 (green), phosphate and K+ (purple) ions (PDB entry [[1o9t]])' scene='49/493038/Cv/4'>
<StructureSection load='1o9t' size='350' side='right' caption='The rat S-adenosylmethionine synthetase complex with methionine, phosphate, ATP (stick model), Mg+2 (green), phosphate and K+ (purple) ions (PDB entry [[1o9t]])' scene='49/493038/Cv/4'>
== Function ==
== Function ==
-
'''S-adenosylmethionine synthetase''' or (MAT) catalyzes the conversion of methionine and ATP to S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi). AdoMet is a methyl donor. The catalytic entity of MAT is a dimer. MAT cofactors are Mg+2 (or Co+2) and K+ ions<ref>PMID:8611562</ref>.
+
'''S-adenosylmethionine synthetase''' or '''S-adenosylmethionine transferase''' (MAT) catalyzes the conversion of methionine and ATP to S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi). AdoMet is a methyl donor. The catalytic entity of MAT is a dimer. MAT cofactors are Mg+2 (or Co+2) and K+ ions<ref>PMID:8611562</ref>.
== Relevance ==
== Relevance ==

Revision as of 09:06, 13 March 2022

The rat S-adenosylmethionine synthetase complex with methionine, phosphate, ATP (stick model), Mg+2 (green), phosphate and K+ (purple) ions (PDB entry 1o9t)

Drag the structure with the mouse to rotate

3D structures of S-adenosylmethionine synthetase

13-March-2022


References

  1. ↑ Takusagawa F, Kamitori S, Markham GD. Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution. Biochemistry. 1996 Feb 27;35(8):2586-96. PMID:8611562 doi:http://dx.doi.org/10.1021/bi952604z
  2. ↑ Mato JM, Alvarez L, Ortiz P, Mingorance J, Duran C, Pajares MA. S-adenosyl-L-methionine synthetase and methionine metabolism deficiencies in cirrhosis. Adv Exp Med Biol. 1994;368:113-7. PMID:7741002
  3. ↑ Gonzalez B, Pajares MA, Hermoso JA, Guillerm D, Guillerm G, Sanz-Aparicio J. Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism. J Mol Biol. 2003 Aug 8;331(2):407-16. PMID:12888348
Retrieved from "http://52.214.119.220/wiki/index.php/Methionine_adenosyltransferase"
Personal tools