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3gyg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of yhjK (haloacid dehalogenase-like hydrolase protein) from Bacillus subtilis== | |
| - | + | <StructureSection load='3gyg' size='340' side='right'caption='[[3gyg]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3gyg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GYG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | '' | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ntdB, yhjK, BSU10540 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gyg OCA], [https://pdbe.org/3gyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gyg RCSB], [https://www.ebi.ac.uk/pdbsum/3gyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gyg ProSAT], [https://www.topsan.org/Proteins/MCSG/3gyg TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NTDB_BACSU NTDB_BACSU]] Involved in the biosynthesis of kanosamine (3-amino-3-deoxy-D-glucose), which is known to have antibiotic and antifungal properties, and to be a precursor of the antibiotic neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose (NTD)). Catalyzes the dephosphorylation of kanosamine 6-phosphate to yield kanosamine. There is a trace amount of activity using glucosamine-6-phosphate.<ref>PMID:14612444</ref> <ref>PMID:23586652</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/3gyg_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gyg ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacsu]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jedrzejczak, R]] | ||
| + | [[Category: Joachimiak, A]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Nocek, B]] | ||
| + | [[Category: Stein, A]] | ||
| + | [[Category: Wu, R]] | ||
| + | [[Category: Antibiotic biosynthesis]] | ||
| + | [[Category: Haloacid dehalogenase-like hydrolase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mcsg]] | ||
| + | [[Category: Pf05116]] | ||
| + | [[Category: Pf08282]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
Current revision
Crystal structure of yhjK (haloacid dehalogenase-like hydrolase protein) from Bacillus subtilis
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