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Siderocalin
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' > | |
| + | __TOC__ | ||
| + | == Function == | ||
| + | '''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | ||
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| + | == Relevance == | ||
| + | Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death<ref>PMID:22728330</ref>. | ||
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| + | == Structural highlights == | ||
| + | Scn-NGAL interacts with the <scene name='48/488406/Cv/4'>siderophore carboxymycobactin where the latter is centered in the protein calyx</scene> making <scene name='48/488406/Cv/5'>multiple interactions including cation-π bonds involving several lysines and arginine</scene><ref>PMID:15642259</ref>. Water molecules are shown as red spheres. <scene name='48/488406/Cv/6'>Fe coordination site</scene>. | ||
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| + | ==3D structures of siderocalin== | ||
| + | [[Siderocalin 3D structures]] | ||
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| + | ==References== | ||
| + | </StructureSection> | ||
| + | <references /> | ||
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| + | [[Category:Topic Page]] | ||
Current revision
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- ↑ Hoette TM, Abergel RJ, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24;130(51):17584-92. doi: 10.1021/ja8074665. PMID:19053425 doi:http://dx.doi.org/10.1021/ja8074665
- ↑ Paragas N, Qiu A, Hollmen M, Nickolas TL, Devarajan P, Barasch J. NGAL-Siderocalin in kidney disease. Biochim Biophys Acta. 2012 Sep;1823(9):1451-8. doi: 10.1016/j.bbamcr.2012.06.014., Epub 2012 Jun 19. PMID:22728330 doi:http://dx.doi.org/10.1016/j.bbamcr.2012.06.014
- ↑ Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK. Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure. 2005 Jan;13(1):29-41. PMID:15642259 doi:10.1016/j.str.2004.10.009
