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2uvs
From Proteopedia
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| - | [[Image:2uvs.png|left|200px]] | ||
| - | + | ==High Resolution Solid-state NMR structure of Kaliotoxin== | |
| - | + | <StructureSection load='2uvs' size='340' side='right'caption='[[2uvs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2uvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Andmu Andmu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ktx|1ktx]], [[2ktx|2ktx]], [[2uvt|2uvt]]</div></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvs OCA], [https://pdbe.org/2uvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvs RCSB], [https://www.ebi.ac.uk/pdbsum/2uvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvs ProSAT]</span></td></tr> |
| - | [[2uvs]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvs_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvs ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Potassium channel toxin|Potassium channel toxin]] | + | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Baldus, M | + | </StructureSection> |
| - | [[Category: Becker, S | + | [[Category: Andmu]] |
| - | [[Category: Korukottu, J | + | [[Category: Large Structures]] |
| - | [[Category: Lange, A | + | [[Category: Baldus, M]] |
| - | [[Category: Pongs, O | + | [[Category: Becker, S]] |
| - | [[Category: Schneider, R | + | [[Category: Korukottu, J]] |
| - | [[Category: Vijayan, V | + | [[Category: Lange, A]] |
| - | [[Category: Zweckstetter, M | + | [[Category: Pongs, O]] |
| + | [[Category: Schneider, R]] | ||
| + | [[Category: Vijayan, V]] | ||
| + | [[Category: Zweckstetter, M]] | ||
[[Category: Amidation]] | [[Category: Amidation]] | ||
[[Category: Ionic channel inhibitor]] | [[Category: Ionic channel inhibitor]] | ||
Current revision
High Resolution Solid-state NMR structure of Kaliotoxin
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