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2v7f

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Revision as of 12:40, 23 March 2022

Structure of P. abyssi RPS19 protein

Structural highlights

2v7f is a 1 chain structure with sequence from "pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RS19E_PYRAB] May be involved in maturation of the 30S ribosomal subunit.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Diamond-Blackfan anemia (DBA) is a rare congenital disease linked to mutations in the ribosomal protein genes rps19, rps24 and rps17. It belongs to the emerging class of ribosomal disorders. To understand the impact of DBA mutations on RPS19 function, we have solved the crystal structure of RPS19 from Pyrococcus abyssi. The protein forms a five alpha-helix bundle organized around a central amphipathic alpha-helix, which corresponds to the DBA mutation hot spot. From the structure, we classify DBA mutations relative to their respective impact on protein folding (class I) or on surface properties (class II). Class II mutations cluster into two conserved basic patches. In vivo analysis in yeast demonstrates an essential role for class II residues in the incorporation into pre-40S ribosomal particles. This data indicate that missense mutations in DBA primarily affect the capacity of the protein to be incorporated into pre-ribosomes, thus blocking maturation of the pre-40S particles.

Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19.,Gregory LA, Aguissa-Toure AH, Pinaud N, Legrand P, Gleizes PE, Fribourg S Nucleic Acids Res. 2007;35(17):5913-21. Epub 2007 Aug 28. PMID:17726054^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gregory LA, Aguissa-Toure AH, Pinaud N, Legrand P, Gleizes PE, Fribourg S. Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19. Nucleic Acids Res. 2007;35(17):5913-21. Epub 2007 Aug 28. PMID:17726054 doi:10.1093/nar/gkm626

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v7f"

@@ Line 3: / Line 3: @@
 <StructureSection load='2v7f' size='340' side='right'caption='[[2v7f]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2v7f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V7F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2v7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7F FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7f OCA], [http://pdbe.org/2v7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v7f RCSB], [http://www.ebi.ac.uk/pdbsum/2v7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7f ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7f OCA], [https://pdbe.org/2v7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7f RCSB], [https://www.ebi.ac.uk/pdbsum/2v7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7f ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RS19E_PYRAB RS19E_PYRAB]] May be involved in maturation of the 30S ribosomal subunit.
+[[https://www.uniprot.org/uniprot/RS19E_PYRAB RS19E_PYRAB]] May be involved in maturation of the 30S ribosomal subunit.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

2v7f

From Proteopedia

Revision as of 12:40, 23 March 2022

Structure of P. abyssi RPS19 protein

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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