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3hhc

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[[Image:3hhc.png|left|200px]]
 
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{{STRUCTURE_3hhc| PDB=3hhc | SCENE= }}
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==Interferon-lambda is functionally an interferon but structurally related to the IL-10 family==
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<StructureSection load='3hhc' size='340' side='right'caption='[[3hhc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hhc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL28B, IFNL3, IFNL4, IL28C, ZCYTO22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhc OCA], [https://pdbe.org/3hhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhc RCSB], [https://www.ebi.ac.uk/pdbsum/3hhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhc ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/IFNL3_HUMAN IFNL3_HUMAN]] Response to antiviral treatment in hepatitis C.
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== Function ==
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[[https://www.uniprot.org/uniprot/IFNL3_HUMAN IFNL3_HUMAN]] Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.<ref>PMID:12469119</ref> <ref>PMID:12483210</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hhc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hhc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambdaR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion, our data show that, although IFN-lambda is functionally an interferon, it is clearly structurally related to members of the IL-10 family. In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively.
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===Interferon-lambda is functionally an interferon but structurally related to the IL-10 family===
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Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.,Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R J Biol Chem. 2009 Jul 31;284(31):20869-75. Epub 2009 May 20. PMID:19457860<ref>PMID:19457860</ref>
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{{ABSTRACT_PUBMED_19457860}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3hhc" style="background-color:#fffaf0;"></div>
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[[3hhc]] is a 4 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHC OCA].
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interferon 3D structures|Interferon 3D structures]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:019457860</ref><references group="xtra"/>
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<references/>
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[[Category: Homo sapiens]]
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__TOC__
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[[Category: Gad, H H.]]
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</StructureSection>
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[[Category: Hamming, O J.]]
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[[Category: Human]]
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[[Category: R., Hartmann.]]
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[[Category: Large Structures]]
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[[Category: Gad, H H]]
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[[Category: Hamming, O J]]
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[[Category: Hartmann, R]]
[[Category: Antiviral]]
[[Category: Antiviral]]
[[Category: Antiviral defense]]
[[Category: Antiviral defense]]

Current revision

Interferon-lambda is functionally an interferon but structurally related to the IL-10 family

PDB ID 3hhc

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