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3hp0

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==Crystal structure of a Putative polyketide biosynthesis enoyl-CoA hydratase (pksH) from Bacillus subtilis==
==Crystal structure of a Putative polyketide biosynthesis enoyl-CoA hydratase (pksH) from Bacillus subtilis==
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<StructureSection load='3hp0' size='340' side='right' caption='[[3hp0]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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<StructureSection load='3hp0' size='340' side='right'caption='[[3hp0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hp0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP0 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HP0 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp0 OCA], [https://pdbe.org/3hp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hp0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp0 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3hp0 TOPSAN]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU17160, pksH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp0 OCA], [http://pdbe.org/3hp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp0 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3hp0 TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/PKSH_BACSU PKSH_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably catalyzes the dehydration of the (S)-3-hydroxy-3-methylglutaryl group attached to PksL.<ref>PMID:16757561</ref> <ref>PMID:17234808</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hp0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hp0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hp0 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hp0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus globigii migula 1900]]
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[[Category: Large Structures]]
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[[Category: Enoyl-CoA hydratase]]
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[[Category: Burley SK]]
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[[Category: Burley, S K]]
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[[Category: Eswaramoorthy S]]
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[[Category: Eswaramoorthy, S]]
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[[Category: Satyanarayana L]]
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[[Category: Structural genomic]]
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[[Category: Swaminathan S]]
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[[Category: Satyanarayana, L]]
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[[Category: Swaminathan, S]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Enoyl coa hydratase]]
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[[Category: Isomerase]]
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[[Category: Lyase]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Polyketide synthase]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of a Putative polyketide biosynthesis enoyl-CoA hydratase (pksH) from Bacillus subtilis

PDB ID 3hp0

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