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Sandbox 1711

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=== Conformation: Closed ===
=== Conformation: Closed ===
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<scene name='90/905640/Closedoverall/1'>closed neurofibromin</scene>
+
In the overall closed <scene name='90/905640/Closedoverall/1'>closed neurofibromin</scene> and inactive conformation of the neurofibromin protein, both sets of the GRD and Sec14-PH domains are rotated in a way that they are inaccessible and inactive. The closed conformation is much more tightly compacted and there is no room for association with the Ras protein.
<scene name='90/905640/Closedoverall/6'>vertical view</scene>
<scene name='90/905640/Closedoverall/6'>vertical view</scene>
=== Domains ===
=== Domains ===

Revision as of 03:36, 28 March 2022

Neurofibromin

Closed conformation of Neurofibromin

Drag the structure with the mouse to rotate

References

  1. ↑ Bergoug M, Doudeau M, Godin F, Mosrin C, Vallee B, Benedetti H. Neurofibromin Structure, Functions and Regulation. Cells. 2020 Oct 27;9(11). pii: cells9112365. doi: 10.3390/cells9112365. PMID:33121128 doi:http://dx.doi.org/10.3390/cells9112365
  2. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

Student Contributors

  • Hannah Luchinski
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