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6hj2

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(New page: '''Unreleased structure''' The entry 6hj2 is ON HOLD until Aug 31 2020 Authors: Granell, M., Delfosse, V., Bourguet, W. Description: Crystal structure of hPXR in complex with dabrafeni...)
Current revision (11:01, 30 March 2022) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6hj2 is ON HOLD until Aug 31 2020
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==Crystal structure of hPXR in complex with dabrafenib==
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<StructureSection load='6hj2' size='340' side='right'caption='[[6hj2]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HJ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=P06:DABRAFENIB'>P06</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1I2, PXR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj2 OCA], [https://pdbe.org/6hj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hj2 RCSB], [https://www.ebi.ac.uk/pdbsum/6hj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN]] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
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Authors: Granell, M., Delfosse, V., Bourguet, W.
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==See Also==
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*[[Pregnane X receptor|Pregnane X receptor]]
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Description: Crystal structure of hPXR in complex with dabrafenib
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Bourguet, W]]
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[[Category: Delfosse, V]]
[[Category: Granell, M]]
[[Category: Granell, M]]
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[[Category: Delfosse, V]]
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[[Category: Nuclear protein]]
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[[Category: Bourguet, W]]
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[[Category: Pregnane x receptor anti-cancer drug endocrine disruptor nuclear receptor]]

Current revision

Crystal structure of hPXR in complex with dabrafenib

PDB ID 6hj2

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