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6tat
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6tat is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the five-fold capsomer of the dArc2 capsid== | |
| + | <SX load='6tat' size='340' side='right' viewer='molstar' caption='[[6tat]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6tat]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAT FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Arc2, CG13941 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tat OCA], [https://pdbe.org/6tat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tat RCSB], [https://www.ebi.ac.uk/pdbsum/6tat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tat ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME]] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication. | ||
| - | + | Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.,Erlendsson S, Morado DR, Cullen HB, Feschotte C, Shepherd JD, Briggs JAG Nat Neurosci. 2020 Feb;23(2):172-175. doi: 10.1038/s41593-019-0569-y. Epub 2020, Jan 6. PMID:31907439<ref>PMID:31907439</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6tat" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Drome]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Briggs, J A.G]] | ||
| + | [[Category: Erlendsson, S]] | ||
| + | [[Category: Morado, D R]] | ||
| + | [[Category: Shepherd, J D]] | ||
| + | [[Category: Darc]] | ||
| + | [[Category: Gag]] | ||
| + | [[Category: Virus]] | ||
| + | [[Category: Virus like particle]] | ||
| + | [[Category: Vlp]] | ||
Current revision
Structure of the five-fold capsomer of the dArc2 capsid
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Categories: Drome | Large Structures | Briggs, J A.G | Erlendsson, S | Morado, D R | Shepherd, J D | Darc | Gag | Virus | Virus like particle | Vlp
