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| - | [[Image:2i44.gif|left|200px]] | |
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| - | {{Structure
| + | ==Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii== |
| - | |PDB= 2i44 |SIZE=350|CAPTION= <scene name='initialview01'>2i44</scene>, resolution 2.04Å
| + | <StructureSection load='2i44' size='340' side='right'caption='[[2i44]]' scene=''> |
| - | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+A+401'>AC1</scene>, <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+A+402'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+B+403'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+B+404'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Residue+C+405'>AC5</scene> and <scene name='pdbsite=AC6:Ca+Binding+Site+For+Residue+C+406'>AC6</scene>
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
| + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I44 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i44 OCA], [https://pdbe.org/2i44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i44 RCSB], [https://www.ebi.ac.uk/pdbsum/2i44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i44 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i44 TOPSAN]</span></td></tr> |
| - | |GENE=
| + | </table> |
| - | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
| + | == Evolutionary Conservation == |
| - | |RELATEDENTRY=
| + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i44 OCA], [http://www.ebi.ac.uk/pdbsum/2i44 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i44 RCSB]</span>
| + | Check<jmol> |
| - | }}
| + | <jmolCheckbox> |
| - | | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/2i44_consurf.spt"</scriptWhenChecked> |
| - | '''Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii'''
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | | + | </jmolCheckbox> |
| - | ==Overview==
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i44 ConSurf]. |
| - | The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
| + | <div style="clear:both"></div> |
| - | | + | __TOC__ |
| - | ==About this Structure==
| + | </StructureSection> |
| - | 2I44 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I44 OCA].
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Burley SK]] |
| - | ==Reference== | + | [[Category: Eswaramoorthy S]] |
| - | Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
| + | [[Category: Swamianthan S]] |
| - | [[Category: Single protein]] | + | |
| - | [[Category: Toxoplasma gondii]] | + | |
| - | [[Category: Burley, S K.]]
| + | |
| - | [[Category: Eswaramoorthy, S.]]
| + | |
| - | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
| + | |
| - | [[Category: Swamianthan, S.]]
| + | |
| - | [[Category: 8817z]]
| + | |
| - | [[Category: hydrolase]]
| + | |
| - | [[Category: new york structural genomix research consortium]]
| + | |
| - | [[Category: nysgxrc]] | + | |
| - | [[Category: phosphatase]] | + | |
| - | [[Category: protein structure initiative]] | + | |
| - | [[Category: psi-2]] | + | |
| - | [[Category: structural genomic]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:39:24 2008''
| + | |
