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2vl7

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[[Image:2vl7.jpg|left|200px]]
 
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==Structure of S. tokodaii Xpd4==
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The line below this paragraph, containing "STRUCTURE_2vl7", creates the "Structure Box" on the page.
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<StructureSection load='2vl7' size='340' side='right'caption='[[2vl7]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl7 OCA], [https://pdbe.org/2vl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl7 ProSAT]</span></td></tr>
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{{STRUCTURE_2vl7| PDB=2vl7 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vl7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in eukaryotes, catalyzing DNA duplex opening localized to the transcription start site or site of DNA damage, respectively. XPD has a 5' to 3' polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ. The xpd gene is the target of mutation in patients with xeroderma pigmentosum, trichothiodystrophy, and Cockayne's syndrome, characterized by a wide spectrum of symptoms ranging from cancer susceptibility to neurological and developmental defects. The 2.25 A crystal structure of XPD from the crenarchaeon Sulfolobus tokodaii, presented here together with detailed biochemical analyses, allows a molecular understanding of the structural basis for helicase activity and explains the phenotypes of xpd mutations in humans.
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'''STRUCTURE OF S. TOKODAII XPD4'''
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Structure of the DNA repair helicase XPD.,Liu H, Rudolf J, Johnson KA, McMahon SA, Oke M, Carter L, McRobbie AM, Brown SE, Naismith JH, White MF Cell. 2008 May 30;133(5):801-12. PMID:18510925<ref>PMID:18510925</ref>
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==Overview==
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The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in eukaryotes, catalyzing DNA duplex opening localized to the transcription start site or site of DNA damage, respectively. XPD has a 5' to 3' polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ. The xpd gene is the target of mutation in patients with xeroderma pigmentosum, trichothiodystrophy, and Cockayne's syndrome, characterized by a wide spectrum of symptoms ranging from cancer susceptibility to neurological and developmental defects. The 2.25 A crystal structure of XPD from the crenarchaeon Sulfolobus tokodaii, presented here together with detailed biochemical analyses, allows a molecular understanding of the structural basis for helicase activity and explains the phenotypes of xpd mutations in humans.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2VL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL7 OCA].
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</div>
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<div class="pdbe-citations 2vl7" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of the DNA repair helicase XPD., Liu H, Rudolf J, Johnson KA, McMahon SA, Oke M, Carter L, McRobbie AM, Brown SE, Naismith JH, White MF, Cell. 2008 May 30;133(5):801-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18510925 18510925]
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*[[Helicase 3D structures|Helicase 3D structures]]
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[[Category: Single protein]]
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== References ==
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[[Category: Sulfolobus tokodaii]]
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<references/>
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[[Category: Carter, L G.]]
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__TOC__
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[[Category: Johnson, K A.]]
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</StructureSection>
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[[Category: Liu, L.]]
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[[Category: Dsm 16993]]
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[[Category: Mcmahon, S A.]]
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[[Category: Large Structures]]
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[[Category: Naismith, J H.]]
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[[Category: Carter, L G]]
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[[Category: Oke, M.]]
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[[Category: Johnson, K A]]
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[[Category: White, M F.]]
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[[Category: Liu, L]]
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[[Category: Zawadski, M.]]
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[[Category: McMahon, S A]]
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[[Category: Naismith, J H]]
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[[Category: Oke, M]]
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[[Category: White, M F]]
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[[Category: Zawadski, M]]
[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:17:58 2008''
 

Current revision

Structure of S. tokodaii Xpd4

PDB ID 2vl7

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