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User:Anna Postnikova/MAT
From Proteopedia
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== Structure == | == Structure == | ||
<StructureSection load='5a1i' size='400' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='5a1i' size='400' side='right' caption='Caption for this structure' scene=''> | ||
| - | <scene name='90/907472/Mat2a/ | + | <scene name='90/907472/Mat2a/3'>MAT2a Subunit</scene> |
MAT consists of a and b subunits. MATa1 and MATa2 are catalytic subunits while MATb is a regulatory subunit. The subunits are encoded on different genes in humans, so they are created separately and can then come together to form various complexes, such as MATab or MATa2 dimers (cite). | MAT consists of a and b subunits. MATa1 and MATa2 are catalytic subunits while MATb is a regulatory subunit. The subunits are encoded on different genes in humans, so they are created separately and can then come together to form various complexes, such as MATab or MATa2 dimers (cite). | ||
Revision as of 15:08, 30 March 2022
Contents |
Methionine adenosyltransferase
MAT synthesizes S-adenosylmethionine from the substrates ATP and methionine. ATP isn’t used as a source of energy like it is in other reactions but gets a methionine added onto the 5th carbon while the three phosphate groups are broken down and released from the active sit. This enzyme is conserved and found in many organisms, so it is essential for life. Problems with this enzyme have been shown to cause diseases such as various cancers.
SAM Formation Mechanism
Function
Structure
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