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7e1a
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Human bile salt exporter ABCB11 in complex with taurocholate== |
| - | + | <StructureSection load='7e1a' size='340' side='right'caption='[[7e1a]], [[Resolution|resolution]] 3.66Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7e1a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1a OCA], [https://pdbe.org/7e1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1a RCSB], [https://www.ebi.ac.uk/pdbsum/7e1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1a ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen, Y]] | ||
| + | [[Category: How, W T]] | ||
| + | [[Category: Wang, L]] | ||
| + | [[Category: Abc transporter]] | ||
| + | [[Category: Liver]] | ||
| + | [[Category: Membrane protein]] | ||
Current revision
Human bile salt exporter ABCB11 in complex with taurocholate
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