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2wc2
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2wc2' size='340' side='right' caption='[[2wc2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | ==Nmr structure of catabolite activator protein in the unliganded state== |
| + | <StructureSection load='2wc2' size='340' side='right'caption='[[2wc2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wc2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WC2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wc2 OCA], [https://pdbe.org/2wc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wc2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wc2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CRP_ECO57 CRP_ECO57]] A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wc2_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wc2_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wc2 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2wc2" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Catabolite gene activator protein|Catabolite gene activator protein]] | + | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Ecobd]] |
| + | [[Category: Large Structures]] | ||
[[Category: Kalodimos, C G]] | [[Category: Kalodimos, C G]] | ||
[[Category: Popovych, N]] | [[Category: Popovych, N]] | ||
[[Category: Tzeng, S R]] | [[Category: Tzeng, S R]] | ||
| + | [[Category: Acetylation]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: Allosteric protein]] | [[Category: Allosteric protein]] | ||
Current revision
Nmr structure of catabolite activator protein in the unliganded state
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Categories: Ecobd | Large Structures | Kalodimos, C G | Popovych, N | Tzeng, S R | Acetylation | Activator | Allosteric protein | Camp | Camp-binding | Catabolite activator protein | Cyclic nucleotide-binding protein | Dna-binding | Dna-binding protein | Nucleotide-binding | Transcription | Transcription regulation | Transcription regulator | Transctiption factor
