This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2woa
From Proteopedia
| Line 3: | Line 3: | ||
<StructureSection load='2woa' size='340' side='right'caption='[[2woa]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2woa' size='340' side='right'caption='[[2woa]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2woa]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2woa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOA FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=576:(3S)-5-(9H-FLUOREN-2-YL)-3-HYDROXYPENTANOIC+ACID'>576</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=576:(3S)-5-(9H-FLUOREN-2-YL)-3-HYDROXYPENTANOIC+ACID'>576</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ycm|1ycm]], [[1os9|1os9]], [[1utt|1utt]], [[1z3j|1z3j]], [[1y93|1y93]], [[2wo8|2wo8]], [[2w0d|2w0d]], [[1os2|1os2]], [[2wo9|2wo9]], [[1ros|1ros]], [[1jk3|1jk3]], [[1utz|1utz]], [[1jiz|1jiz]], [[1rmz|1rmz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ycm|1ycm]], [[1os9|1os9]], [[1utt|1utt]], [[1z3j|1z3j]], [[1y93|1y93]], [[2wo8|2wo8]], [[2w0d|2w0d]], [[1os2|1os2]], [[2wo9|2wo9]], [[1ros|1ros]], [[1jk3|1jk3]], [[1utz|1utz]], [[1jiz|1jiz]], [[1rmz|1rmz]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2woa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2woa OCA], [https://pdbe.org/2woa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2woa RCSB], [https://www.ebi.ac.uk/pdbsum/2woa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2woa ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
Revision as of 11:12, 6 April 2022
MMP12 complex with a beta hydroxy carboxylic acid
| |||||||||||
Categories: Human | Large Structures | Macrophage elastase | Amour, A J | Baddeley, S J | Brown, D | Convery, M A | Egan, D | Gaines, S | Gross, J W | Herbert, S | Holmes, I P | Lorthioir, O | Martin, S L | Singh, O M.P | Smith, R H | Strelow, J M | Walker, A | Watson, S P | Calcium | Disulfide bond | Extracellular matrix | Glycoprotein | Hydrolase | Matrix metalloprotease mmp-12 complex structure | Metal-binding | Metalloprotease | Polymorphism | Protease | Secreted | Zinc | Zymogen

