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3hym

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{{Seed}}
 
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[[Image:3hym.jpg|left|200px]]
 
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==Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure==
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The line below this paragraph, containing "STRUCTURE_3hym", creates the "Structure Box" on the page.
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<StructureSection load='3hym' size='340' side='right'caption='[[3hym]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hym]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC26, C9orf17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CDC16, ANAPC6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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{{STRUCTURE_3hym| PDB=3hym | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hym OCA], [https://pdbe.org/3hym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hym RCSB], [https://www.ebi.ac.uk/pdbsum/3hym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hym ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CDC26_HUMAN CDC26_HUMAN]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<ref>PMID:18485873</ref> [[https://www.uniprot.org/uniprot/CDC16_HUMAN CDC16_HUMAN]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hym_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hym ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.
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===Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure===
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Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.,Wang J, Dye BT, Rajashankar KR, Kurinov I, Schulman BA Nat Struct Mol Biol. 2009 Sep;16(9):987-9. Epub 2009 Aug 9. PMID:19668213<ref>PMID:19668213</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3HYM is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYM OCA].
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<div class="pdbe-citations 3hym" style="background-color:#fffaf0;"></div>
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[[Category: Homo sapiens]]
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== References ==
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[[Category: Dye, B T.]]
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<references/>
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[[Category: Kurinov, I.]]
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__TOC__
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[[Category: Rajashankar, K R.]]
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</StructureSection>
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[[Category: Schulman, B A.]]
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[[Category: Human]]
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[[Category: Wang, J.]]
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[[Category: Large Structures]]
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[[Category: Dye, B T]]
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[[Category: Kurinov, I]]
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[[Category: Rajashankar, K R]]
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[[Category: Schulman, B A]]
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[[Category: Wang, J]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Anaphase promoting complex]]
[[Category: Anaphase promoting complex]]
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[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 13:45:11 2009''
 

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Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure

PDB ID 3hym

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