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| - | ==Alpha-2 Macroglobulin==
| + | #REDIRECT [[6tav]] This PDB entry is obsolete and replaced by 6tav |
| - | <StructureSection load='4acq' size='340' side='right' caption='[[4acq]], [[Resolution|resolution]] 4.30Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4acq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACQ FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bv8|1bv8]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4acq RCSB], [http://www.ebi.ac.uk/pdbsum/4acq PDBsum]</span></td></tr>
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| - | </table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | I'm your Venus: The crystal structure of the human methylamine-induced form of alpha(2) -macroglobulin (alpha(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of alpha(2) M.
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| - | The Crystal Structure of Human alpha(2) -Macroglobulin Reveals a Unique Molecular Cage.,Marrero A, Duquerroy S, Trapani S, Goulas T, Guevara T, Andersen GR, Navaza J, Sottrup-Jensen L, Gomis-Ruth FX Angew Chem Int Ed Engl. 2012 Jan 31. doi: 10.1002/anie.201108015. PMID:22290936<ref>PMID:22290936</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Andersen, G R]]
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| - | [[Category: Duquerroy, S]]
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| - | [[Category: Gomis-Ruth, F X]]
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| - | [[Category: Goulas, T]]
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| - | [[Category: Guevara, T]]
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| - | [[Category: Marrero, A]]
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| - | [[Category: Navaza, J]]
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| - | [[Category: Sottrup-Jensen, L]]
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| - | [[Category: Trapani, S]]
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| - | [[Category: Blood plasma inhibitor]]
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| - | [[Category: Conformational change]]
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| - | [[Category: Hydrolase inhibitor]]
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| - | [[Category: Irreversible proteinase inhibitor]]
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| - | [[Category: Proteinase inhibitor]]
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