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2xhd

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[[Image:2xhd.png|left|200px]]
 
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==Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor==
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The line below this paragraph, containing "STRUCTURE_2xhd", creates the "Structure Box" on the page.
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<StructureSection load='2xhd' size='340' side='right'caption='[[2xhd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xhd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7T9:N-[(2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL]-2-PROPANESULFONAMIDE'>7T9</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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-->
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wjx|2wjx]], [[2wjw|2wjw]]</div></td></tr>
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{{STRUCTURE_2xhd| PDB=2xhd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhd OCA], [https://pdbe.org/2xhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhd RCSB], [https://www.ebi.ac.uk/pdbsum/2xhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xhd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS penetrant molecule with an excellent pharmacokinetic profile across preclinical species, which is well tolerated and is also orally bioavailable in humans.
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===CRYSTAL STRUCTURE OF N-((2S)-5-(6-FLUORO-3-PYRIDINYL)-2,3-DIHYDRO-1H-INDEN-2-YL)-2-PROPANESULFONAMIDE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE HUMAN GLUA2 RECEPTOR===
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Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfo namide, a Novel Clinical AMPA Receptor Positive Modulator.,Ward SE, Harries M, Aldegheri L, Andreotti D, Ballantine S, Bax BD, Harris AJ, Harker AJ, Lund J, Melarange R, Mingardi A, Mookherjee C, Mosley J, Neve M, Oliosi B, Profeta R, Smith KJ, Smith PW, Spada S, Thewlis KM, Yusaf SP J Med Chem. 2010 Jul 8. PMID:20614889<ref>PMID:20614889</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xhd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20614889}}, adds the Publication Abstract to the page
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20614889 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_20614889}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human]]
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[[2xhd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHD OCA].
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[[Category: Large Structures]]
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[[Category: Aldegheri, L]]
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==Reference==
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[[Category: Andreotti, D]]
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<ref group="xtra">PMID:020614889</ref><references group="xtra"/>
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[[Category: Ballantine, S]]
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[[Category: Homo sapiens]]
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[[Category: Bax, B D]]
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[[Category: Aldegheri, L.]]
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[[Category: Harker, A J]]
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[[Category: Andreotti, D.]]
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[[Category: Harries, M]]
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[[Category: Ballantine, S.]]
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[[Category: Harris, A J]]
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[[Category: Bax, B D.]]
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[[Category: Lund, J]]
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[[Category: Harker, A J.]]
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[[Category: Melarange, R]]
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[[Category: Harries, M.]]
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[[Category: Mingardi, A]]
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[[Category: Harris, A J.]]
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[[Category: Mookherjee, C]]
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[[Category: Lund, J.]]
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[[Category: Mosley, J]]
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[[Category: Melarange, R.]]
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[[Category: Neve, M]]
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[[Category: Mingardi, A.]]
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[[Category: Oliosi, B]]
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[[Category: Mookherjee, C.]]
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[[Category: Profeta, R]]
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[[Category: Mosley, J.]]
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[[Category: Smith, K J]]
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[[Category: Neve, M.]]
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[[Category: Smith, P W]]
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[[Category: Oliosi, B.]]
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[[Category: Spada, S]]
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[[Category: Profeta, R.]]
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[[Category: Thewlis, K M]]
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[[Category: Smith, K J.]]
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[[Category: Ward, S E]]
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[[Category: Smith, P W.]]
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[[Category: Yusaf, S P]]
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[[Category: Spada, S.]]
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[[Category: Ion channel]]
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[[Category: Thewlis, K M.]]
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[[Category: Transport protein]]
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[[Category: Ward, S E.]]
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[[Category: Yusaf, S P.]]
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Current revision

Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor

PDB ID 2xhd

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